2025 Multiprofessional Critical Care Review: Adult Online-5: Acute Respiratory Failure: Difficult Cases

Video Transcription

Video Summary

This lecture discusses acute respiratory failure, particularly in the context of COVID-19. The speaker explores whether respiratory failure in COVID-19 is unique and how respiratory effort can contribute to lung injury. The lecture highlights the different sub-phenotypes observed in COVID-19 patients and the potential role of patient self-inflicted lung injury (PCILI). It also discusses the importance of assessing and managing lung injury, including the concept of mechanical power and its association with mortality. The lecture touches on the significance of asynchrony and the impact of respiratory effort on lung injury. It suggests the use of parameters like driving pressure and respiratory rate to estimate mechanical power and optimize ventilation strategies. The lecture concludes with the exploration of potential therapeutic targets to mitigate stress and strain on the lung, such as the measurement of P.01 as an indicator of respiratory drive.

Keywords

acute respiratory failure

COVID-19

lung injury

mechanical power

patient self-inflicted lung injury

ventilation strategies

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