Advanced Pharmacotherapy in Critical Care Online-A, B, C-IWA: Updates in the Management of Alcohol Withdrawal (Deepali Dixit, PharmD, BCCCP, FCCM)

A, B, C-IWA: Updates in the Management of Alcohol Withdrawal (Deepali Dixit, PharmD, BCCCP, FCCM)

Video Transcription

Video Summary

In this video transcript, Dr. Dipali Dixit discusses updates in the management of alcohol withdrawal, covering topics such as pathophysiology, clinical complications, scoring tools, and pharmacotherapy. Alcohol use disorder affects millions in the US, with significant impact on hospital admissions and ICU stays. Alcohol withdrawal complications include seizures, delirium tremens, and increased mortality risk. The pathophysiology involves GABA and NMDA receptor dysregulation leading to brain hyperexcitability. Clinical manifestations include autonomic hyperactivity, alcohol hallucinosis, withdrawal seizures, and delirium tremens. Objective scoring tools such as SIVA and MIND can help assess withdrawal severity. Benzodiazepines are the mainstay of treatment, with options including phenobarbital, dexmedetomidine, ketamine, gabapentin, and baclofen as adjuncts. Studies have shown promise in reducing symptoms and benzo requirements. Ongoing research is needed to optimize management strategies for alcohol withdrawal in critically ill patients.

Keywords

alcohol withdrawal

management

pathophysiology

clinical complications

scoring tools

pharmacotherapy

GABA

NMDA receptor

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