Advanced Pharmacotherapy in Critical Care Online-Multimodal Approach to Vasopressors (Patrick M. Wieruszewski, PharmD, BCCCP)

Multimodal Approach to Vasopressors (Patrick M. Wieruszewski, PharmD, BCCCP)

Video Transcription

Video Summary

Pharmacist Patrick Wieroszewski discusses a multimodal approach to vasopressors in patients with vasodilatory shock. Vasodilatory shock can result from various causes like sepsis, postoperative vasoplegia, and anaphylaxis, leading to decreased perfusing pressures and inadequate oxygen delivery. Traditional stepwise escalation of vasopressors may lead to prolonged hypoperfusion and multiple organ failure. The Surviving Sepsis Campaign recommends using norepinephrine as a first-line agent, with vasopressin and epinephrine as additional options. Studies show that some patients may not respond to vasopressors, highlighting the need for personalized vasopressor approaches. The use of vasopressors like vasopressin and angiotensin II, along with norepinephrine, can improve hemodynamic responsiveness and outcomes in shock patients. Implementing Joint Commission standards for titratable medications and utilizing smart pumps can enhance the safety and effectiveness of vasopressor therapies. An integrated approach to vasopressor therapy, focusing on rapid restoration of organ perfusion and personalized patient care, is essential in managing shock effectively.

Keywords

vasopressors

vasodilatory shock

sepsis

norepinephrine

vasopressin

epinephrine

organ perfusion

personalized care

smart pumps

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