Advanced Pharmacotherapy in Critical Care Online-Take a Deep Breath: The Role of Inhaled Anesthetics in ICU Sedation (Dusan Hanidziar, MD, PhD)

Take a Deep Breath: The Role of Inhaled Anesthetics in ICU Sedation (Dusan Hanidziar, MD, PhD)

Video Transcription

Video Summary

Dr. Dusan Hanijiar, an anesthesiologist and intensivist at Massachusetts General Hospital, discusses the role of inhaled anesthetics in ICU sedation in a presentation focused on sedation management involving prescribers, pharmacists, and nurses in critical care settings. He explains the mechanisms of action of volatile anesthetics like isoflurane and their advantages over intravenous sedatives, particularly in facilitating rapid awakening, reducing opioid use, and managing patient ventilator dyssynchrony. The efficacy and safety of isoflurane sedation compared to propofol was studied in a Phase III trial showing non-inferiority and opioid-sparing effects. Additionally, ongoing trials are examining the use of isoflurane sedation in ICU patients with hypoxemic respiratory failure. Dr. Hanijiar emphasizes the importance of balancing sedation levels to address patient ventilator desynchrony and discusses the potential benefits of isoflurane sedation in this context. Ultimately, the use of volatile anesthetics like isoflurane in ICU sedation presents promising opportunities for optimizing patient care and outcomes.

Keywords

Dusan Hanijiar

Massachusetts General Hospital

ICU sedation

Inhaled anesthetics

Isoflurane

Ventilator dyssynchrony

Opioid-sparing effects

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