Advanced Pharmacotherapy in Critical Care Online-To Stress or Not to Stress: Controversies and Updates in Steroid Use (Mohammed Aldhaeefi, PharmD, BCCCP, FACC)

To Stress or Not to Stress: Controversies and Updates in Steroid Use (Mohammed Aldhaeefi, PharmD, BCCCP, FACC)

Video Transcription

Video Summary

The speaker, Mohamed Abdaifi, discussed controversies and updates in steroid use, focusing on steroid therapy in severe community-acquired pneumonia, sepsis, and COVID-19 infection. He highlighted the evolving role of steroids, optimal regimens, minimizing adverse effects, and alternative strategies in case of shortages. The presentation covered pharmacology, the hypothalamus-pituitary-adrenal axis physiology, guidelines on steroid use, and findings from studies like the CAPE-COD and ESCAPE trials. In sepsis management, the adrenal and approaches trials were reviewed. In COVID-19 treatment, the recovery and CODIX trials showed benefits of dexamethasone. Strategies for managing steroid shortages were also discussed, emphasizing the importance of screening for safe and effective steroid use. Overall, corticosteroids can be beneficial in certain ICU settings when used appropriately.

Keywords

steroid use

community-acquired pneumonia

sepsis

COVID-19 infection

pharmacology

corticosteroids

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