Advanced Pharmacotherapy in Critical Care Online-Will These Change My Practice? The Role of Novel Antimicrobials for Gram-Negative Bacteria in the ICU (Sunish Shah, PharmD, BCIDP)

Will These Change My Practice? The Role of Novel Antimicrobials for Gram-Negative Bacteria in the ICU (Sunish Shah, PharmD, BCIDP)

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Video Transcription

Video Summary

The video features Sunesh Shah, an infectious diseases pharmacist, discussing novel antimicrobials, focusing on beta-lactams for treating gram-negative bacteremia in the ICU. Shah covers Ambler classification of beta-lactamases, classes A-D, highlighting ESBLs and carbapenemases like KPCs and metallo-beta-lactamases. He delves into newly approved broad-spectrum antibiotics' spectra of activity and resistance mechanisms in gram-negative bacteria. Shah discusses novel agents like ceftolazane tazobactam, ceftazidime avibactam, meropenem vabor bactam, imipenem relabactam, cefiderocol, and sulbactam derlabactam. He reviews clinical data, treatment guidelines, dosing considerations, and real-world studies for each agent. Shah emphasizes the importance of choosing appropriate agents based on resistance profiles and highlights the growing role of metallo-beta-lactamases and treating resistant infections. He also provides case scenarios and comparative insights into these novel antimicrobials. Shah concludes by stressing the significance of understanding mechanisms of resistance and the evolving epidemiology for optimizing treatment strategies.

Keywords

Sunesh Shah

antimicrobials

beta-lactams

gram-negative bacteremia

carbapenemases

resistance mechanisms

novel agents

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