Current Concepts in Pediatric Critical Care-14: When Does the Pediatric Patient Become an Adult? (Hot Topic)

14: When Does the Pediatric Patient Become an Adult? (Hot Topic)

Video Transcription

Video Summary

In this video, Gideon Stitt, a critical care pharmacist and research fellow, discusses the challenges of dosing medications for pediatric patients who are approaching adulthood. He explains the basic pharmacokinetic changes that occur as children grow older, including alterations in absorption, distribution, metabolism, and elimination of drugs. Stitt emphasizes the importance of understanding these maturational changes in order to optimize dosing recommendations for larger children. He explores different methods of scaling clearance and volume of distribution, including linear scaling and allometric scaling. Stitt highlights the significance of allometry in population pharmacokinetic modeling and its application in determining optimal dosing for pediatric patients. He also discusses the implications of obesity on dosing and presents a study that provides recommendations for dosing of commonly prescribed medications in critically ill obese children. Stitt concludes by emphasizing the importance of considering the specific characteristics of each drug and patient when determining dosing strategies for larger pediatric patients.

Asset Caption

Gideon Stitt, PharmD, BCPPS, BCCCP

Keywords

pediatric pharmacokinetics

medication dosing

allometric scaling

critical care pharmacy

obesity implications

drug metabolism

pharmacokinetic modeling

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