Current Concepts in Pediatric Critical Care-5: Sepsis Induced Organ Dysfunction

Video Transcription

Video Summary

The video discusses phenotyping sepsis-induced multiple organ dysfunction syndrome (MODS) in children. It covers various phenotypes including thrombocytopenia-associated MODS (TAMOF), sequential MODS, immunoparalysis, and macrophage activation syndrome (MAS). The presenter provides case scenarios and outlines the proposed phenotypes, their underlying mechanisms, and clinical manifestations. The importance of identifying these phenotypes is highlighted, as patients with multiple organ failure and an inflammatory phenotype have a higher risk of mortality. The timing of onset for each phenotype is discussed, and it is suggested that targeted therapies should be implemented once a phenotype is identifiable. The presenter also introduces potential treatment options for each phenotype, such as plasma exchange for TAMOF, GM-CSF for immunoparalysis, and IL-1 receptor blockade for MAS. The video concludes by mentioning ongoing clinical trials in adults and children to further investigate these treatment options.

Asset Caption

Julie C. Fitzgerald, MD, PhD, FCCM

Keywords

sepsis-induced MODS

children

phenotypes

treatment options

clinical trials

inflammatory phenotype

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