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Deep Dive: Acute Kidney Injury and Organ Crosstalk ...
Pharmacologic Considerations During Critical Illne ...
Pharmacologic Considerations During Critical Illness With Failing Kidneys
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Video Transcription
Video Summary
The presentation discussed the importance of proper dosing of medications in critically ill patients, particularly focusing on those with acute kidney injury (AKI) and the need for renal replacement therapy. Dosing considerations were highlighted for antibiotics such as zosyn and vancomycin, with an emphasis on achieving therapeutic drug concentrations and balancing the risks of underdosing and overdosing. The challenges of estimating glomerular filtration rate (GFR) using serum creatinine and cystatin C were discussed, along with the impact of renal replacement modalities on drug clearance. The speaker provided dosing recommendations for zosyn and vancomycin in patients undergoing continuous renal replacement therapy, emphasizing the need for individualized dosing strategies based on patient characteristics and specific factors. Transitions between different renal replacement modalities were also addressed in optimizing drug dosing. Ultimately, a personalized approach was recommended to ensure effective and safe medication dosing in critically ill patients with AKI.
Keywords
medication dosing
critically ill patients
acute kidney injury
renal replacement therapy
antibiotics
glomerular filtration rate
continuous renal replacement therapy
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