Deep Dive: Acute Kidney Injury and Organ Crosstalk Online-Pharmacologic Considerations During Critical Illness With Failing Kidneys

Pharmacologic Considerations During Critical Illness With Failing Kidneys

Video Transcription

Video Summary

The presentation discussed the importance of proper dosing of medications in critically ill patients, particularly focusing on those with acute kidney injury (AKI) and the need for renal replacement therapy. Dosing considerations were highlighted for antibiotics such as zosyn and vancomycin, with an emphasis on achieving therapeutic drug concentrations and balancing the risks of underdosing and overdosing. The challenges of estimating glomerular filtration rate (GFR) using serum creatinine and cystatin C were discussed, along with the impact of renal replacement modalities on drug clearance. The speaker provided dosing recommendations for zosyn and vancomycin in patients undergoing continuous renal replacement therapy, emphasizing the need for individualized dosing strategies based on patient characteristics and specific factors. Transitions between different renal replacement modalities were also addressed in optimizing drug dosing. Ultimately, a personalized approach was recommended to ensure effective and safe medication dosing in critically ill patients with AKI.

Keywords

medication dosing

critically ill patients

acute kidney injury

renal replacement therapy

antibiotics

glomerular filtration rate

continuous renal replacement therapy

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