Deep Dive: Advances in the Care of Infectious Diseases in the ICU-Biomarkers of Infection in the ICU: Procalcitonin and More

Video Transcription

Video Summary

The video is a presentation by Dr. Samir Khadri on the topic of biomarkers of infection in the ICU, with a focus on procalcitonin. Dr. Khadri discusses the challenges in diagnosing sepsis and the uncertainty around antibiotic treatment. He explains that biomarkers can help differentiate bacterial infection from non-bacterial infection in sepsis cases. Procalcitonin is a biomarker that shows promise in this regard, as it is released in response to bacterial infection. However, its performance is not consistent across all cases, and false positive results can occur in certain conditions. Dr. Khadri explores the use of procalcitonin in guiding antibiotic initiation, prognosis, and treatment escalation in ICU patients, as well as its role in COVID-19. He presents evidence from various studies and meta-analyses on the effectiveness of procalcitonin in these areas. He highlights the limitations and challenges in interpreting the results and provides recommendations based on the latest guidelines. Dr. Khadri emphasizes the need for further research to better understand the use and impact of procalcitonin in clinical practice, particularly in the context of evolving antibiotic stewardship practices.

Asset Caption

Sameer S. Kadri

Keywords

biomarkers

infection

procalcitonin

sepsis

antibiotics

ICU

COVID-19

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