Deep Dive: Microbiomes – An Update on Our Ten Trillion Friends and How to Keep That Friendship Going-The Microbiome in ARDS and Other Critical Illness States

Video Transcription

Video Summary

The speaker, an associate professor at NYU School of Medicine, discussed the role of the microbiome in acute respiratory distress syndrome (ARDS) and critical illness. They highlighted the heterogeneity of diseases like sepsis and ARDS and emphasized the importance of understanding the complex microbial community in the body and its impact on the immune system and pathogen behavior. The discussion focused on the gut-lung axis, microbial translocation, and microbial interactions in the lower airways. The speaker presented research findings on the microbial burden in ARDS patients, the association of specific microbes with poor outcomes, and the potential for microbial signatures to predict prognosis. They emphasized the need to consider factors disrupting the microbiome, such as antibiotics and diet, and suggested potential interventions like fecal microbiota transplantation. Overall, the talk stressed the importance of unraveling the microbiome's role in inflammatory injury in critical illnesses to improve treatment approaches.

Asset Caption

Leopoldo N. Segal

Keywords

microbiome

acute respiratory distress syndrome

ARDS

critical illness

gut-lung axis

microbial community

immune system

microbial interactions

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