Deep Dive: Microbiomes – An Update on Our Ten Trillion Friends and How to Keep That Friendship Going -- Online (DEEP24CON)-Microbiomes – An Update on our Ten Trillion Friends and How to Keep that Friendship Going Handout

Microbiomes – An Update on our Ten Trillion Friends and How to Keep that Friendship Going Handout

Pdf Summary

The document discusses the significance of the microbiome in critical care settings, particularly its role in health, illness, and critical conditions like sepsis and acute respiratory distress syndrome (ARDS). It explores the impact of critical illness on the microbiome and the potential interventions such as probiotics, prebiotics, and fecal microbial transplants in treating respiratory infections. Insights into the gut microbiota's contribution to organ function in critically ill patients are outlined, emphasizing the effects of antibiotics on gut microbiota and clinical outcomes.<br /><br />Researchers aim to understand the complex pathways through which gut microbiota influence end-organ function and dysfunction, with ongoing longitudinal studies shedding light on the microbiome's role in critical illnesses. The document delves into the gut-lung axis and how microbial balance affects disease pathogenesis, clinical outcomes, and interventions in critical care. Various studies highlight the importance of nutritional support in optimizing gut microbiome health during critical illness, focusing on enteral feeding formulas and parenteral nutrition's effects.<br /><br />Moreover, the discussion extends to the use of combined omic approaches to predict mortality in ARDS patients based on the host transcriptome and microbial signatures. Findings from these studies suggest that dysbiosis in critically ill patients, particularly in COVID-19 cases, is associated with poor outcomes. The intricate interaction between the host immune response, microbial composition, and clinical outcomes in critical illness illustrates the complexity of managing the microbiome in intensive care settings.

Keywords

microbiome

critical care

health

illness

sepsis

acute respiratory distress syndrome

ARDS

probiotics

prebiotics

fecal microbial transplants

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