Deep Dive: Saving the Kidneys-AKI Biomarkers: A New Way to Use Tools You Have

Video Transcription

Video Summary

The speaker discussed the use of readily available biomarkers in the diagnosis and care of patients with acute kidney injury (AKI). They emphasized the heterogeneity of AKI and the need to improve diagnostic precision. The speaker highlighted the importance of urine output as a biomarker, as it captures a subset of patients missed by serum creatinine alone and identifies patients with worse outcomes. They also mentioned the use of the furosemide stress test (FST) as a cheap and easy way to assess tubular function early on in AKI patients. The FST accurately predicts AKI progression in adults, but more prospective studies are needed in pediatric patients. The speaker also discussed the use of fluid overload as a biomarker, which can identify high-risk AKI sub-phenotypes. Furthermore, they highlighted the importance of considering the kinetics of serum creatinine and the duration and severity of AKI in prognostication. The speaker concluded by providing a framework for risk stratification and management of AKI patients based on these biomarkers.

Asset Caption

Natalja L. Stanski

Keywords

acute kidney injury

urine output

furosemide stress test

fluid overload

biomarkers

prognostication

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