Deep Dive: Saving the Kidneys-Biomarker-Based Enrichment to Target AKI

Video Transcription

Video Summary

The speaker discusses the topic of biomarker-based enrichment to target acute kidney injury (AKI). They emphasize the importance of precision medicine and enrichment in patient management. They explain the concepts of prognostic and predictive enrichment and how they can be applied to AKI. Prognostic enrichment tools, such as the renal angina index and TMP2-IGFBP7 biomarkers, are discussed, along with their role in identifying high-risk patients and implementing appropriate interventions. The speaker also explores the use of CCL14 as a biomarker for predicting the persistence of AKI. Furthermore, they highlight the need for predictive enrichment tools and mention angiotensin-2 as a potential candidate for targeted therapy in patients with vasodilatory shock and AKI. The speaker concludes by emphasizing the importance of utilizing these tools in clinical practice and for enrollment in clinical trials, as well as the need for further research in predictive enrichment strategies for AKI management.

Asset Caption

Natalja L. Stanski

Keywords

biomarker-based enrichment

acute kidney injury

precision medicine

prognostic enrichment

predictive enrichment

CCL14 biomarker

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