Multiprofessional Critical Care Review: Pediatric (2023)-Pharmacology: Five Things You Need to Know

Video Transcription

Video Summary

This video discusses five important points about pharmacology. The speaker starts by discussing pharmacokinetic properties, including absorption, distribution, metabolism, and elimination. They emphasize how these properties are influenced by age and critical illness. The speaker then compares pharmacokinetic principles as they relate to first-order and zero-order kinetics, highlighting the importance of understanding drug effects and dosing adjustments in the ICU. Next, they define pharmacology as the science of drugs, while pharmacokinetics refers to the study of drug time courses. They explain that pharmacodynamics focuses on drug reactions in living systems, including exposure-response relationships. The speaker provides a detailed overview of the four pillars of pharmacokinetics, discussing factors that influence drug absorption, distribution, metabolism, and elimination. They also touch on pharmacokinetics in special populations, such as neonates and infants. Lastly, the video explores alternative routes of drug administration, including aerosolization, endotracheal administration, and intraosseous administration. It concludes with an explanation of first-order and zero-order elimination, the concept of half-life, and the use of loading doses to achieve therapeutic concentrations quickly.

Keywords

pharmacology

pharmacokinetic properties

absorption

distribution

metabolism

elimination

ICU

pharmacodynamics

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