Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-10

10_Vasoactive Agents

Pdf Summary

The document summarizes a presentation on vasoactive agents and support in pediatric critical care. Vasoactive agents are commonly used in ICUs to manage myocardial or circulatory dysfunction through mechanisms involving adrenergic receptors and direct intracellular effects. These agents can impact myocardial contractility, heart rate, systemic vascular resistance, and cardiac output. The presentation discusses the G protein subtypes and adrenergic receptor locations and actions related to vasoconstriction, vasodilation, contractility, and chronotropic effects. Various vasoactive agents such as phenylephrine, norepinephrine, epinephrine, dopamine, dobutamine, and isoproterenol are highlighted, each acting on different receptors. Additionally, the role of other agents like sodium nitroprusside as a nitric oxide donor and nicardipine as a calcium channel blocker is explained. The importance of understanding the mechanisms of action and selecting the appropriate agent based on the underlying disease and physiology is emphasized for optimal patient care in the ICU setting.

Keywords

vasoactive agents

pediatric critical care

adrenergic receptors

myocardial contractility

systemic vascular resistance

G protein subtypes

phenylephrine

norepinephrine

sodium nitroprusside

nicardipine

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