Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-12

12_Primary Acquired Immunodeficiencies

Pdf Summary

The document provides an overview of primary and acquired immunodeficiencies, focusing on the components of the innate and acquired immune systems. Primary immunodeficiencies are characterized by recurrent infections, poor response to therapy, and family history of immunodeficiency. The text details specific cellular defects in neutrophils and lymphocytes, such as DiGeorge Syndrome and X-linked agammaglobulinemia. It also discusses non-cellular elements like complement deficiency and immunoglobulin deficiencies. The document delves into infections associated with primary immunodeficiencies and secondary causes like transplantation, malignancy, and HIV/AIDS. It highlights immune function in critical illness, emphasizing immunoparalysis and potential treatments to address it. Furthermore, it mentions unintended immunomodulation factors and non-immune causes of recurrent infections. The summary underlines the significance of understanding primary and acquired immunodeficiencies, their impact on immune function, and the implications for critical care management.

Keywords

primary immunodeficiencies

acquired immunodeficiencies

innate immune system

acquired immune system

neutrophil defects

lymphocyte defects

complement deficiency

immunoglobulin deficiencies

immunoparalysis

critical care management

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