Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-16

16_Sedation Analgesia

Pdf Summary

The document discusses a presentation on analgesia, sedation, and neuromuscular blockade in pediatric intensive care units (PICU) by Dr. Sapna R. Kudchadkar from Johns Hopkins School of Medicine. Key points include understanding different drug classes, recognizing conditions like malignant hyperthermia, and issues related to neuromuscular weakness. The presentation covers the uses of neuromuscular blocking drugs, such as facilitating intubation and maintaining optimal surgical conditions. It also delves into the differences between depolarizing and non-depolarizing agents, as well as the reversal of non-depolarizing agents. Various sedatives and analgesics like benzodiazepines, propofol, ketamine, opioids, and dexmedetomidine are discussed with their mechanisms of action and potential side effects. Local anesthetics and their classes are also explored, along with considerations for systemic absorption and management of toxicity. The presentation emphasizes the importance of understanding the sedation continuum and recognizing the appropriate use of drugs based on their effects and potential complications.

Keywords

analgesia

sedation

neuromuscular blockade

pediatric intensive care

malignant hyperthermia

neuromuscular blocking drugs

sedatives

analgesics

local anesthetics

sedation continuum

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