Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-18

18_Immunosupressed

Pdf Summary

The document discusses the care of immunosuppressed children, particularly those who have undergone solid organ and stem cell transplants. It covers topics such as the mechanisms and side effects of immunosuppressive drugs, common pathogens responsible for infections post-transplant, and complications in pediatric patients. Specific infections such as those caused by viruses (CMV, VZV, HSV), and fungi (Candida, Aspergillus) are outlined along with their clinical manifestations and treatments. The text also delves into specific issues related to hematopoietic stem cell transplants like graft versus host disease, sinusoidal obstruction syndrome, and transplant-associated thrombotic microangiopathy. For solid organ transplant recipients, hyperacute rejection, acute rejection, chronic rejection, and post-transplant lymphoproliferative disorder are highlighted. Key takeaway points emphasize the importance of a multidisciplinary approach in caring for immunocompromised patients and the need for tailored prophylaxis and treatment strategies for opportunistic infections. The text concludes by encouraging questions and interactions related to the presented material.

Keywords

immunosuppressed children

solid organ transplants

stem cell transplants

immunosuppressive drugs

post-transplant infections

graft versus host disease

opportunistic infections

pediatric transplant complications

multidisciplinary care

prophylaxis strategies

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