Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-24

24_Pharmacology

Pdf Summary

The document summarizes a presentation on pharmacology by Tom Moran, a PharmD, covering key concepts such as medication pharmacokinetic properties related to age and critical illness, pharmacokinetics and ontogeny, first and zero-order kinetics, and definitions related to pharmacology. It discusses absorption and bioavailability factors including patient-specific and drug-specific factors. The impact of developmental factors on drug distribution, metabolism phases, and drug elimination through hepatic and renal processes are explained. Further details are provided on drug metabolism, ontogeny of drug metabolism, and elimination mechanisms. The document also covers steady state concentrations, loading doses for achieving steady state, and the significance of half-life in determining dosing intervals. Pharmacokinetic principles such as zero and first-order elimination kinetics and the implications of drug concentration on elimination are discussed. Additionally, clinical scenarios like renal replacement therapy and extracorporeal elimination are mentioned. The presentation aims to educate healthcare professionals on these pharmacological principles to optimize medication dosing and management in various patient populations.

Keywords

pharmacology

pharmacokinetics

medication

bioavailability

drug metabolism

half-life

renal processes

loading doses

elimination kinetics

clinical scenarios

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