Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-Caring for the Immunosuppressed Child: Solid Organ and Stem Cell

Video Transcription

Video Summary

This video discusses the mechanisms of action and side effects of common immune suppressive drugs used in oncology and transplant patients, the common pathogens responsible for infections in post-transplant patients, and the complications of transplantation in pediatric patients. It focuses on exogenous immune suppression. The video also presents several case studies to illustrate the concepts discussed. <br /><br />The presenter explains that corticosteroids are potent immune suppressive drugs that directly suppress pro-inflammatory gene transcription and promote anti-inflammatory gene transcription. They also promote lymphocyte apoptosis. Other drugs, such as chemotherapeutic agents and immunosuppressant drugs, work by blocking cellular reproduction. The presenter discusses the mechanisms and toxicities of these drugs. <br /><br />The presenter then discusses different types of infections that immune-compromised patients are susceptible to, including bacterial, viral, fungal, and protozoal infections. The presenter highlights the importance of considering patient-specific factors and local antibiograms when selecting empiric antibiotic therapy. The presenter also mentions complications of transplantation, such as sinusoidal obstruction syndrome, graft-versus-host disease, and idiopathic pneumonia syndrome. The presenter emphasizes the need for a multidisciplinary approach in the care of immune-compromised patients.

Keywords

immune suppressive drugs

oncology

pathogens

infections

corticosteroids

chemotherapeutic agents

lymphocyte apoptosis

transplantation complications

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