Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-Caring for the Immunosuppressed Child: Solid Organ and Stem Cell

Caring for the Immunosuppressed Child: Solid Organ and Stem Cell

Video Transcription

Video Summary

Dr. Jennifer Muczynski presents on caring for immunocompromised children, particularly those who have undergone solid organ or stem cell transplants. The talk covers immune suppression, including CAR T-cell therapy and its risks like cytokine release syndrome (treated with biologics). She highlights infections like CMV, varicella, HSV, and adenovirus, detailing their specific threats to immunocompromised patients. Dr. Muczynski discusses fungal infections, notably mucormycosis, cryptococcus, and histoplasmosis. She addresses complications in transplant care, such as GVHD, VOD/SOS, and TMA. In acute care, distinguishing between organ rejection and infection is crucial due to differing treatments. Emphasis is placed on anti-rejection drugs and the importance of close coordination with transplant teams to balance immune suppression and infection management. Multidisciplinary support is essential for patient survival, encompassing meticulous monitoring and understanding drug interactions.

Keywords

immunocompromised children

solid organ transplant

CAR T-cell therapy

GVHD

infection management

multidisciplinary support

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