Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-Hepatic Failure and Organ Transplantation

Video Transcription

Video Summary

The video discusses key aspects of hepatic failure and organ transplantation, emphasizing fundamental knowledge crucial for patient care. The speaker highlights the importance of interpreting the pathophysiologic parameters of liver failure and understanding its bimodal distribution across different age groups. In newborns, the primary causes include metabolic and gestational alloimmune liver diseases, while in school-age children and teenagers, Tylenol poisoning is common. Critical signs of liver failure include hepatic encephalopathy and hypoglycemia. Besides, hepatorenal syndrome is a major concern due to renal vasoconstriction. Management focuses on early recognition, maintaining normal blood volume, metabolic interventions, and considering extracorporeal liver support therapies like MARS. Peritransplant and post-transplant care includes monitoring for hepatic arterial thrombus and biliary complications. Overall, monitoring metabolic parameters and supportive care are essential due to the limited therapeutic interventions available for liver failure.

Keywords

hepatic failure

organ transplantation

hepatic encephalopathy

Tylenol poisoning

extracorporeal liver support

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