Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-Pathophysiology of Pediatric Sepsis

Video Transcription

Video Summary

The speaker discusses sepsis, emphasizing its complex pathophysiology and the spectrum of responses it triggers. Sepsis isn’t a standalone diagnosis but a syndrome resulting from infection and characterized by varying degrees of inflammation, abnormal perfusion, and organ dysfunction. Older nomenclature classified sepsis through stages (SIRS, sepsis, severe sepsis, and septic shock) based on inflammatory response and organ dysfunction. More recent Sepsis-3 and Phoenix criteria focus on life-threatening organ dysfunction. Pediatric sepsis often presents differently from adult sepsis, with a notable tendency towards cardiogenic shock. The interaction of the immune system (innate and adaptive responses), coagulation imbalance, and endothelial dysfunction underpins the condition. Recognizing sepsis involves persistent focus on the infection source and understanding the risk factors for severe outcomes such as MODS. The presentation hints at the importance of evolving clinical approaches and the potential value of identifying sepsis subphenotypes for more targeted treatment.

Keywords

sepsis

pathophysiology

organ dysfunction

pediatric sepsis

immune response

clinical approaches

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