Multiprofessional Critical Care Review: Pediatric 2024 (MCCRCP24ON)-Pharmacology

Video Transcription

Video Summary

Dr. Thomas Moran, a PharmD and Director of Clinical Pharmacy at Lurie Children's, addresses the complexities of pharmacokinetics and pharmacodynamics in pediatric critical care. The presentation, initially created by Gideon Stitt, delves into key pharmacological concepts like absorption, bioavailability, distribution, metabolism, and excretion (ADME). Moran discusses how factors like particle size, solubility, lipophilicity, and patient-specific conditions such as age, gastric pH, and regional blood flow impact drug absorption. He also explains drug distribution, volume of distribution, and the significance of factors like cardiac output and protein binding. Metabolism is covered through phases involving CYP enzymes, and the role of pharmacogenomics is briefly acknowledged. The elimination process focuses on renal excretion and its variability, especially with modalities like renal replacement therapy and ECMO. Key pharmacokinetic principles such as half-life, steady state, and loading doses are emphasized to aid in clinical decision-making.

Keywords

Pediatric Pharmacokinetics

Pharmacodynamics

Drug Absorption

Metabolism

Renal Excretion

Pharmacogenomics

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