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Multiprofessional Critical Care Review: Pediatric ...
Primary and Acquired Immunodeficiencies
Primary and Acquired Immunodeficiencies
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Video Transcription
Video Summary
In this video transcript, Dr. Asya Golnik discusses primary and acquired immunodeficiencies and their relevance in the Pediatric Intensive Care Unit (PICU) setting. She explains the components of the immune system, including barriers (e.g. skin), non-cellular elements (e.g. complement), and cellular defenses (e.g. neutrophils and T/B lymphocytes). <br /><br />Dr. Golnik goes on to discuss specific disorders and defects of the immune system, such as neutropenia and neutrophil dysfunction, lymphocyte deficiencies (e.g. DiGeorge syndrome), immunoglobulin deficiencies (e.g. X-linked agammaglobulinemia), complement deficiencies, and acquired immunodeficiencies. She emphasizes the importance of recognizing the signs and symptoms of these conditions, as well as planning appropriate treatments.<br /><br />The video also covers secondary or acquired immunodeficiencies commonly seen in critical illness, including immunoparalysis, lymphopenia, and acquired hypoglobulinemias. Dr. Golnik highlights the increased risk of nosocomial infections in these patients and discusses potential treatments for immunoparalysis.<br /><br />Finally, she mentions that not all recurrent infections are immune-mediated, and that other causes such as mucous membrane or skin abnormalities, obstruction, foreign bodies, congenital issues, neurologic issues, and metabolic disorders should be considered.
Keywords
immunodeficiencies
Pediatric Intensive Care Unit
immune system components
specific immune system disorders
acquired immunodeficiencies
secondary immunodeficiencies
treatment of immune system disorders
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