Neuropharmacology - Live-Neuropharmacology

Video Transcription

Video Summary

The webcast, hosted by Krista Ohananobleza, Medical Director at Baptist Memorial Hospital and Associate Professor of Neurology at the University of Tennessee, discusses neuropharmacology, focusing on the reversal of anticoagulation and antiplatelet agents, as well as the treatment of status epilepticus and ICU delirium. The session includes presentations by clinical pharmacists Nicole C. Davis, Andrew Webb, and Salia Farouk from leading hospitals.<br /><br />Nicole Davis covers the reversal of various anticoagulants like warfarin, factor Xa inhibitors, dabigatran, heparin, and low molecular weight heparins. She emphasizes practical strategies, such as the importance of understanding half-lives, renal function, and specific reversal agents like four-factor PCC, idarucizumab, and protamine.<br /><br />Andrew Webb addresses the pharmacotherapy of status epilepticus, emphasizing an algorithmic approach to treatment. He highlights benzodiazepines as first-line emergent therapy and discusses the ESET trial, which compares levetiracetam, fosphenytoin, and valproate. Webb also covers refractory and super-refractory treatments, including the use of propofol, midazolam, and pentobarbital, and notes the significance of early, appropriate dosing.<br /><br />Salia Farouk discusses ICU delirium, pointing out the multifactorial etiology, high incidence, and complex pathophysiology. She emphasizes the limitations of pharmacologic interventions and highlights non-pharmacologic approaches as primary preventive measures. For treatment, dexmedetomidine is suggested for intubated patients where agitation impedes extubation, while routine use of antipsychotics is generally not recommended.<br /><br />The webcast concludes with a Q&A, addressing practical questions about dosing, drug interactions, and specific clinical scenarios. Recordings will be available on mysccm.org within five to seven business days for further reference.

Keywords

neuropharmacology

anticoagulation

antiplatelet agents

status epilepticus

ICU delirium

reversal agents

pharmacotherapy

non-pharmacologic approaches

clinical pharmacists

Q&A session

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