Neuropharmacology - Online (NEURWEB24BON)-Neuropharmacology

Video Transcription

Video Summary

The webcast on neuropharmacology covered a wide range of topics, focusing primarily on the management of anticoagulant reversal, status epilepticus, and ICU delirium. The session featured experts Nicole C. Davis, Andrew Webb, and Salia Farouk, who provided detailed presentations and addressed audience questions.<br /><br />Nicole Davis discussed anticoagulation reversal strategies, focusing on how to reverse specific anticoagulants such as warfarin, factor Xa inhibitors (e.g., apixaban, rivaroxaban), and dabigatran. She highlighted the importance of considering factors such as the time since the last dose, renal function, and drug half-lives. The presentation stressed the need for evidence-based dosing strategies, including fixed-dose and weight-based approaches.<br /><br />Andrew Webb's talk on status epilepticus emphasized the sequential medication management based on current guidelines. First-line treatment involves aggressive administration of parenteral benzodiazepines like lorazepam or midazolam. If seizures persist, urgent therapy with anti-seizure medications such as levetiracetam, phenytoin, or valproate is recommended. Webb underscored the necessity of rapid and high-quality pre-hospital care and continuous EEG monitoring.<br /><br />Salia Farouk focused on ICU delirium, distinguishing between hyperactive, hypoactive, and mixed types. She discussed the multifactorial pathophysiology, including inflammatory cytokines and neurotransmitter imbalances. Farouk advocated for non-pharmacologic interventions as primary management and emphasized the limited role of pharmacologic treatments. Dexmedetomidine was recommended for agitation preventing extubation, while routine use of antipsychotics was not supported except in specific acute agitation scenarios.<br /><br />The Q&A session tackled various practical concerns, including the choice and dosing of medications, the role of benzodiazepines, and specific case management strategies, providing valuable insights into neuropharmacological best practices.<br /><br />In conclusion, the webcast underscored the importance of evidence-based approaches in managing neuropharmacological emergencies, highlighting specific therapeutic strategies and the essential role of comprehensive patient assessment and individualized care.

Keywords

neuropharmacology

anticoagulant reversal

status epilepticus

ICU delirium

Nicole C. Davis

Andrew Webb

Salia Farouk

benzodiazepines

anti-seizure medications

evidence-based strategies

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