SCCM Resource Library-180-Day Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Randomized Clinical Trial

180-Day Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Randomized Clinical Trial

Video Transcription

Video Summary

The speaker presented the results of the Remap-Cap trial, which is a platform trial evaluating multiple treatments for community-acquired pneumonia (CAP) and COVID-19. They focused on the outcomes of the critically ill patients in the trial. The trial used a Bayesian design and randomized patients into different domains or treatment groups. The results showed that interleukin-6 receptor antagonists and antiplatelets had a high probability of improving patient outcomes at six months, with reductions in mortality and no significant impact on quality of life or disability. However, some interventions, such as hydroxychloroquine and combination antiviral therapy, were associated with increased mortality. The speaker emphasized the importance of measuring longer-term outcomes, such as survival free of major disability and with an acceptable quality of life, which can be more important to patients. They concluded that short-term outcomes can be used to make rapid changes and recommendations during a pandemic, as they are associated with longer-term outcomes.

Asset Subtitle

Research, Infection, 2023

Asset Caption

Type: two-hour concurrent | Late-Breaking Studies Affecting Patient Outcomes (SessionID 9000007)

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area Infection

Membership Level Professional

Membership Level Select

Tag Outcomes Research

Tag COVID-19

Year 2023

Keywords

Remap-Cap trial

community-acquired pneumonia

COVID-19

interleukin-6 receptor antagonists

antiplatelets

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