SCCM Resource Library-A Multimodal Approach: When Should We Reach Beyond Norepinephrine and Vasopressin?

A Multimodal Approach: When Should We Reach Beyond Norepinephrine and Vasopressin?

Video Transcription

Video Summary

The presentation highlights the evolving strategies in the use of vasopressors, particularly focusing on the role of angiotensin II in managing hypotension and septic shock. Norepinephrine remains the recommended first-line vasopressor, with vasopressin and epinephrine suggested as subsequent additions. However, there's ongoing debate about these protocols. The ATHOS-3 clinical trial repositioned angiotensin II as an effective vasopressor, especially in patients with high-output vasopressor-refractory shock. Findings showed that patients often exhibit an imbalance in angiotensin I to II, which has implications for survival rates. Angiotensin II demonstrated improved hemodynamics and better outcomes in patients with this imbalance, especially those with lower baseline doses of other vasopressors. Additionally, angiotensin II may enhance oxygenation, offering potential benefits for those with acute respiratory distress syndrome. The discussion suggests a future in precision-based vasopressor management to more effectively target and improve patient outcomes.

Asset Caption

One-Hour Concurrent Session | Rethinking Vasopressors: Evolving Evidence and Emerging Concepts in Vasopressor Administration

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

vasopressors

angiotensin II

hypotension

septic shock

ATHOS-3 trial

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