SCCM Resource Library-A Storm Brewing in the Lungs: The Impact of Mechanical Ventilation and Hypoxia on Immunology

A Storm Brewing in the Lungs: The Impact of Mechanical Ventilation and Hypoxia on Immunology

Video Transcription

Video Summary

John Riley, an assistant professor at the University of Pennsylvania, discussed the impact of mechanical ventilation and hypoxia on immunology at a conference. He highlighted the potential for mechanical ventilation to worsen lung injury through biotrauma, a ventilator-induced inflammatory response. He emphasized the benefits of lung-protective strategies, such as low tidal volume ventilation, to minimize biotrauma. Riley also explored how hypoxia, a key feature of acute respiratory distress syndrome (ARDS), can drive inflammation through pathways like hypoxia-inducible factor (HIF) signaling. He suggested that targeting these mechanisms could lead to novel therapeutic strategies.

Asset Caption

One-Hour Concurrent Session | Induced Immunosuppression in the ICU

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

mechanical ventilation

biotrauma

lung-protective strategies

hypoxia

acute respiratory distress syndrome

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