SCCM Resource Library-ACCM Distinguished Investigator, Discovery Grant Recipient, SCCM-Weil Research Grant Recipient, Discovery SARI-PREP Update

ACCM Distinguished Investigator, Discovery Grant Recipient, SCCM-Weil Research Grant Recipient, Discovery SARI-PREP Update

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Video Transcription

Video Summary

The talk covered the complexities of pulmonary physiology, mechanical ventilation strategies, and their impact on clinical outcomes, particularly in ARDS patients. The speaker recounted a personal research journey beginning with bedside observations during medical fellowship and delved into the debate over appropriate PEEP levels, referencing multiple studies with mixed results on high vs. low PEEP settings. The talk highlighted the use of trans-pulmonary pressure measurements over airway pressures to guide mechanical ventilation, supported by imaging studies showing lung collapse correlation with trans-pulmonary pressure. A patient case was discussed where esophageal balloon catheters were used to measure pleural pressure, guiding appropriate PEEP adjustments, improving patient outcomes. Two trials, EPVENT1 and EPVENT2, were highlighted, showing mixed success in using esophageal pressure-guided PEEP. The speaker emphasized the need for precise trial designs to account for patient variability in recruitability, aiming for a ventilation strategy incorporating both trans-pulmonary pressure and driving pressure for improved mortality. The presentation concluded with lessons on the importance of bedside research, mentorship, teamwork, and maintaining enthusiasm in scientific inquiry.

Asset Caption

One-Hour Concurrent Session | ACCM Distinguished Investigator, Discovery Grant Recipient, SCCM-Weil Research Grant Recipient, Discovery SARI-PREP Update

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

pulmonary physiology

mechanical ventilation

ARDS

PEEP levels

trans-pulmonary pressure

esophageal balloon catheters

EPVENT trials

bedside research

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