SCCM Resource Library-ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals

ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals - 2

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Video Transcription

Video Summary

The presentation focuses on managing hepatorenal syndrome (HRS) and acute kidney injury in liver disease patients. Terlopressin, in combination with albumin, is highlighted as the preferred treatment by both ASLD and ESL guidelines due to its effectiveness. Alternatives like norepinephrine and the less effective combination of mitadrine plus octreotide are also discussed. Terlopressin functions by lowering splenic blood flow and portal pressure, redistributing intravascular volume centrally. Consideration is given to patient-specific factors, such as timing and creatinine levels, as early treatment and lower creatinine improve outcomes. Additionally, using terlopressin requires careful monitoring to avoid adverse effects like respiratory failure, especially in patients with potential liver transplant listings. Cost and ICU usage factors also influence the choice of treatment. Ultimately, liver transplantation is emphasized as the definitive solution for long-term management of HRS and associated complications.

Asset Caption

ACE Symposia | ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

hepatorenal syndrome

terlopressin

acute kidney injury

liver transplantation

albumin

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