SCCM Resource Library-ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals

ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals

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Video Transcription

Video Summary

Dr. Dean Karvelas, a specialist in critical care and hepatology at the University of Alberta, hosted a symposium addressing the management of acute kidney injury (AKI) and multi-organ failure in patients with decompensated cirrhosis and acute-on-chronic liver failure (ACLF). The symposium included an overview of the condition, its pathophysiology, and treatment strategies. ACLF is characterized by an exaggerated inflammatory response leading to high mortality without a liver transplant. The European CLIF definition of ACLF involves six organ failures akin to the SOFA score used in critical care. Managing these patients often requires ICU admission for circulatory, respiratory, and hematologic support, particularly in AKI, linked to poor outcomes. Dr. Karvelas discussed current treatment strategies, such as the use of vasoconstrictive agents and renal replacement therapies, emphasizing the dynamic assessment of patients' volume status and individualized treatment plans to optimize outcomes, including possible bridging to liver transplantation.

Asset Caption

ACE Symposia | ACE Symposium: ICU Management of HRS/AKI and Multiorgan Failure in Patients With Decompensating Cirrhosis - This program is supported by an educational grant from Mallinckrodt Pharmaceuticals

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

acute kidney injury

acute-on-chronic liver failure

multi-organ failure

decompensated cirrhosis

treatment strategies

liver transplant

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