SCCM Resource Library-AED Prophylaxis: Treating Something That Isn't There

Video Transcription

Video Summary

In this video, Sean Rowe, an associate professor of clinical pharmacy, discusses the Neurocritical Care Guidelines for the use of anti-seizure drugs for seizure prophylaxis. He explains the guideline process, which involves developing clinical questions, conducting systematic reviews, and synthesizing evidence. The guideline focuses on four disease states: traumatic brain injury, aneurysmal subarachnoid hemorrhage, intracerebral hemorrhage, and supratentorial surgery. Rowe presents the results of the meta-analyses conducted for each disease state, highlighting the lack of statistical difference in preventing early seizures, late seizures, mortality, and adverse events in traumatic brain injury. He also notes that there was a worse outcome in functional outcome for patients with intracerebral hemorrhage who received anti-seizure drugs. In supratentorial surgery, levitiracetam showed an improvement in preventing early seizures compared to phenytoin. The committee is currently working on the final recommendations and plans to publish them throughout the year.

Asset Subtitle

Quality and Patient Safety, 2023

Asset Caption

Type: one-hour concurrent | Guideline Review: Status Epilepticus and Seizure Prophylaxis (SessionID 1119989)

Meta Tag

Content Type Presentation

Knowledge Area Quality and Patient Safety

Membership Level Professional

Membership Level Select

Tag Evidence Based Medicine

Year 2023

Keywords

Neurocritical Care Guidelines

Anti-seizure drugs

Seizure prophylaxis

Disease states

Meta-analyses

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