SCCM Resource Library-Adaptive Immune Function and Immunoparalysis in Children With Septic Shock

Adaptive Immune Function and Immunoparalysis in Children With Septic Shock

Video Transcription

Video Summary

Diego Cruz, a Pediatric Infectious Disease Fellow at Nationwide Children's Hospital, discusses the concept of immune paralysis in children with septic shock, focusing on both the innate and adaptive immune responses. He explains that immune paralysis is associated with adverse outcomes in septic children and highlights the need to understand biomarkers of lymphocyte function in this setting. Through their study, they found that septic children with immune paralysis had a suppression of both the innate and adaptive immune response. This information could be used to identify patients for future clinical trials of immunomodulatory therapies and as biomarkers of immune function recovery.

Asset Subtitle

Sepsis, Pediatrics, 2023

Asset Caption

Type: star research | Star Research Presentations: Biomarkers II, Pediatrics (SessionID 30008)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Pediatrics

Membership Level Professional

Membership Level Select

Tag Pediatrics

Tag Shock

Year 2023

Keywords

immune paralysis

septic shock

innate immune response

adaptive immune response

biomarkers of lymphocyte function

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