SCCM Resource Library-Advances in Stroke Reperfusion Therapy: A Moving Target

Video Transcription

Video Summary

This video provides an update on the use of thrombolytic therapies for the management of stroke. The speaker discusses the currently approved thrombolytic therapies, including alteplase and tenecteplase, and highlights their differences in terms of dosing strategy, kinetic characteristics, and cost. The speaker also emphasizes the importance of advanced imaging techniques such as MRI and perfusion imaging in selecting patients for thrombolytic therapy. The use of advanced imaging allows for the identification of patients with salvageable tissue and helps guide treatment decisions beyond the traditional time window. The speaker reviews the results of various trials, including EXTEND-IA, SWIFT-PRIME, DIFFUSE-3, and DON, which have shown the benefits of endovascular therapy in both the early and late time windows. The speaker also discusses the challenges and unanswered questions in the field, such as the selection of patients for basilar artery occlusion and the treatment of patients with large core infarcts. Overall, the video highlights the significant advances and potential of thrombolytic therapies in stroke management, and emphasizes the need for further research and clinical studies in this area.

Asset Subtitle

Neuroscience, Procedures, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Recognize new thrombolytic therapies in the management of stroke
Assess new mechanical thrombolytic therapies in the management of stroke

Advances in Thrombolytic Therapy
Gretchen M. Brophy

Mechanical Thrombectomy
Gregory W. Albers

Meta Tag

Content Type Presentation

Knowledge Area Neuroscience

Knowledge Area Procedures

Knowledge Level Advanced

Membership Level Select

Tag Stroke

Tag Neuroimaging

Tag Cerebral Blood Flow

Year 2021

Keywords

thrombolytic therapies

stroke management

alteplase

tenecteplase

advanced imaging techniques

endovascular therapy

patient selection

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