SCCM Resource Library-Alactic Base Excess Is an Independent Predictor of Death in Sepsis: A Propensity Score Analysis

Alactic Base Excess Is an Independent Predictor of Death in Sepsis: A Propensity Score Analysis

Video Transcription

Video Summary

The presenter, Joaquin Cantos, discussed a study called "Allactic Base Excesses and Independent Projector of Death in sepsis." This study aimed to evaluate the role of Allactic Base Excess (ABE) in predicting outcomes in septic patients, independent of kidney function markers. ABE is a measure of renal function in the acid-base balance of septic patients. The study used a retrospective cohort design and included 1,178 adult septic patients. The patients were divided into three groups based on ABE values: negative ABE, neutral ABE, and positive ABE. The primary outcome was in-hospital mortality, and the secondary outcomes included mortality in patients with preserved kidney function and the association between lactic acidosis and acidemia. The results showed that negative ABE was an independent risk factor for mortality in septic patients, even in those with preserved kidney function. The study concluded that negative ABE reflects acid-base disturbances in septic patients with preserved kidney function and could be used as a tool to detect subclinical acute kidney injury.

Asset Subtitle

Sepsis, 2023

Asset Caption

Type: star research | Star Research Presentations: Sepsis (SessionID 30011)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Membership Level Professional

Membership Level Select

Tag Sepsis

Year 2023

Keywords

Allactic Base Excess

septic patients

kidney function markers

mortality

acid-base balance

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