SCCM Resource Library-August Journal Club Webcast: Spotlight on Pharmacy (2022)

Video Transcription

Video Summary

In this video transcript, three presenters discuss different topics related to pharmacy. The first presenter discusses a study comparing the effectiveness of intravenous tenecteplase and alteplase for acute ischemic stroke in Canada. The study concluded that tenecteplase was non-inferior to alteplase in terms of disability outcomes. The second presenter discusses a study on the effect of therapeutic drug monitoring (TDM) based dose optimization of piperacillin-tazobactam on sepsis-related organ dysfunction in patients with sepsis. The study found that TDM-based dose optimization led to higher attainment of pharmacokinetic and pharmacodynamic targets. The third presenter discusses a study comparing propofol and midazolam sedation in patients with cardiogenic shock. The study found that propofol sedation did not lead to more catecholamine requirements compared to midazolam sedation. The study also found that propofol sedation was associated with lower mortality rates and less bleeding events. Overall, the presenters highlighted the potential benefits of these interventions and the need for further research in these areas.

Asset Subtitle

Pharmacology, Neuroscience, Sepsis, 2022

Asset Caption

"The Journal Club: Spotlight on Pharmacy webcast series focuses on pharmacy topics. This event is held on the third Friday of each month and features lively discussion and in-depth presentations on the latest research.

Brittany Harnicher, PharmD
Menon BK, Buck BH, Singh N, et al; AcT Trial Investigators. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet. 2022 Jul 16;400(10347):161-169.

Amoreena Most, PharmD
Hagel S, Bach F, Brenner T, et al; TARGET Trial Investigators. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Med. 2022 Mar;48(3):311-321.

Emily Duff, PharmD
Scherer C, Kleeberger J, Kellnar A, et al. Propofol versus midazolam sedation in patients with cardiogenic shock: an observational propensity-matched study. J Crit Care. 2022 May 5;71:154051.

Follow the conversation at #SCCMCPPJC."

Meta Tag

Content Type Webcast

Knowledge Area Pharmacology

Knowledge Area Neuroscience

Knowledge Area Sepsis

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Tag Cerebral Ischemia

Tag Antibiotics

Tag Shock

Year 2022

Keywords

pharmacy

intravenous tenecteplase

alteplase

acute ischemic stroke

disability outcomes

therapeutic drug monitoring

piperacillin-tazobactam

sepsis-related organ dysfunction

propofol sedation

midazolam sedation

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