SCCM Resource Library-Balanced Crystalloids Versus Saline in Critically Ill Adults: Systematic Review and Meta-Analysis

Balanced Crystalloids Versus Saline in Critically Ill Adults: Systematic Review and Meta-Analysis

Video Transcription

Video Summary

Professor Simon Finfer, from the George Institute for Global Health and University College London, presented the findings of a systematic review and meta-analysis comparing balanced crystalloids versus saline in critically ill adults at a conference. The study examined the use of intravenous fluid resuscitation in critically ill patients and the shift from normal saline to balanced or buffered solutions. The research included observational data, before and after studies, and high-quality randomized controlled trials. The results indicated that balanced salt solutions may reduce 90-day mortality by a range of 9% relative reduction to a 1% relative increase. The analysis showed an 89.5% probability of lower mortality with balanced salt solutions compared to saline. Patients with sepsis appeared to benefit from balanced salt solutions, while patients with traumatic brain injury may benefit more from saline. Further investigation through a patient-level meta-analysis is underway. The full publication is available at NEJM Evidence and the George Institute Plus media site.

Asset Subtitle

Neuroscience, Trauma, 2022

Asset Caption

Optimal cerebral perfusion pressure during delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Meta Tag

Content Type Presentation

Knowledge Area Neuroscience

Knowledge Area Trauma

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Cerebral Blood Flow

Tag Neurotrauma

Year 2022

Keywords

Professor Simon Finfer

balanced crystalloids

saline

intravenous fluid resuscitation

critically ill patients

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