SCCM Resource Library-Basic/Translational Science

Video Transcription

Video Summary

The video transcript discusses several publications in basic and translational research. The first study highlights the role of red blood cells as immune sensors in critical illness. The researchers found that red blood cells express pattern recognition receptors, specifically TLR9 receptors, which can respond to danger signals and modulate the immune response. The study also showed that red blood cells carrying bacterial and mitochondrial DNA can induce splenic sequestration, hemophagocytosis, and a pro-inflammatory response. The second study focuses on the immune modulatory effects of angiotensin II in preclinical sepsis models. It found that angiotensin II can augment the innate immune response through the angiotensin type 1 receptor, leading to increased phagocytosis capacity and bacterial clearance. The last two papers discuss cell-based therapies for pediatric diffuse midline gliomas, particularly the efficacy of anti-GD2 CAR-T cell therapy. Preclinical studies showed that anti-GD2 CAR-T cells effectively targeted and reduced tumor burden in diffuse midline glioma samples. An ongoing phase one clinical trial has shown manufacturing feasibility and early signs of clinical efficacy, although notable on-target toxicities, such as tumor inflammation-associated neurotoxicity, have occurred and require aggressive immune modulation and neuro-intensive care.

Asset Subtitle

Research, Quality and Patient Safety, 2023

Asset Caption

Type: year in review | Year in Review: Pediatrics (SessionID 2000008)

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area Quality and Patient Safety

Membership Level Professional

Membership Level Select

Tag Clinical Research Design

Tag Evidence Based Medicine

Year 2023

Keywords

red blood cells

immune sensors

TLR9 receptors

angiotensin II

anti-GD2 CAR-T cell therapy

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