SCCM Resource Library-Beyond Cultures: Biomarkers and Rapid Molecular Tests to Improve Antimicrobial Use

Video Transcription

Video Summary

Dr. Ryan Maves, a professor of medicine and anesthesiology, discusses the use of rapid molecular tests to improve antimicrobial use in the intensive care unit (ICU). The problem of increasing antimicrobial drug resistance is addressed, and the importance of timely administration of appropriate antibiotics is emphasized. Dr. Maves presents several studies highlighting the impact of delayed treatment on patient mortality. He also discusses the challenges in distinguishing between bacterial, fungal, viral, and non-infectious causes of severe inflammation, and the need for a balance between appropriate empiric therapy and antimicrobial resistance. Different methods for rapid testing, such as PCR, antigen detection, and biomarkers, are explored. Dr. Maves focuses on assays that evaluate respiratory tract and bloodstream infections, and the potential benefits of using multiplex PCR-based studies and mass spectrometry for rapid pathogen identification. The limitations and ongoing need for culture-based methods are also discussed. Overall, the aim is to provide actionable and rapid information to improve patient care and outcomes in the ICU.

Asset Subtitle

Infection, Pharmacology, Quality and Patient Safety, 2022

Asset Caption

Increasing rates of antimicrobial drug resistance in the community and in the ICU imperil our ability to care for patients with sepsis and septic shock. In this session, we will review the clinical features that clinicians can use to guide rational antimicrobial drug use, new and emerging diagnostic tests that help us make the right choice of drugs more rapidly, and the data for novel antimicrobial agents, including beta-lactam/beta-lactamase inhibitors and tetracycline derivates, that may support the care of infected patients in the ICU.

Meta Tag

Content Type Presentation

Knowledge Area Infection

Knowledge Area Pharmacology

Knowledge Area Quality and Patient Safety

Knowledge Level Advanced

Membership Level Select

Tag Antibiotics

Tag Pharmacokinetics Pharmacodynamics

Tag Evidence Based Medicine

Year 2022

Keywords

rapid molecular tests

antimicrobial use

intensive care unit

antimicrobial drug resistance

timely administration

appropriate antibiotics

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