SCCM Resource Library-Beyond Cytokines: Alternative Targets for Host-Based Blood Purification

Video Transcription

Video Summary

In this video, the speaker discusses alternative targets for host-based blood purification in the treatment of sepsis. They highlight the need for extracorporeal blood therapy due to the increased incidence of drug-resistant pathogens and a lack of novel antimicrobial therapies. The speaker explains the immune response to pathogen exposure, including the release of cytokines and the potential for organ dysfunction. They then discuss three filters or cartridges that are currently being evaluated in clinical trials. The first is the Seraph cartridge, which mimics the function of the endothelial glycocalyx and has shown promise in reducing mortality in patients with severe COVID-19. The second is the polymyxin B cartridge, which binds to endotoxins and has had conflicting results in clinical trials. And the third is the selective cytopheretic device, which removes activated neutrophils and monocytes from circulation, leading to immunomodulation. The speaker concludes by stating that while there is growing evidence for the use of these therapies, many questions still need to be answered through further research.

Asset Subtitle

Procedures, Sepsis, 2023

Asset Caption

Type: one-hour concurrent | Extracorporeal Blood Purification for Shock Redux: Where Are We in 2023? (SessionID 1119343)

Meta Tag

Content Type Presentation

Knowledge Area Procedures

Knowledge Area Sepsis

Membership Level Professional

Membership Level Select

Tag Extracorporeal Membrane Oxygenation ECMO

Tag Cytokines

Year 2023

Keywords

host-based blood purification

extracorporeal blood therapy

cytokines release

Seraph cartridge

immunomodulation

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