SCCM Resource Library-Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle-Income Country

Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle-Income Country

Video Transcription

Video Summary

The speaker discusses the use of biomarker-based risk stratification in pediatric sepsis, specifically in low-middle income countries. They evaluated the performance of Persevere 2, a risk stratification tool using five biomarkers and platelets, in septic children in Pakistan. The study found that Persevere 2 accurately discriminated mortality with an area under the curve of 0.83, even in a cohort with double the mortality rate compared to other studies. The addition of specific biomarkers related to endotheliopathy and coagulation showed potential for improving risk stratification. The study suggests that biomarker-based strategies may be effective in low-middle income countries.

Asset Subtitle

Research, Worldwide Data, 2023

Asset Caption

Type: star research | Star Research Presentations: Biomarkers II, Pediatrics (SessionID 30008)

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area Worldwide Data

Membership Level Professional

Membership Level Select

Tag Outcomes Research

Tag Epidemiology Outcomes

Year 2023

Keywords

biomarker-based risk stratification

pediatric sepsis

low-middle income countries

Persevere 2

mortality rate

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