SCCM Resource Library-Caring for the Critically Ill Transplant Patient

Video Transcription

Video Summary

The video transcript discusses the care of critically ill transplant patients. The first speaker emphasizes that transplant patients are complicated to care for due to the multiple medications they require and the unique syndromes they can develop. The talks in this session focus on the basics of immunosuppressive medications, prophylactics, and the management of stem cell transplant patients. The second speaker discusses the array of immunosuppressive medications and infection prophylactics used in transplant patients, particularly in the critical care setting. The speaker explains the goals of immunosuppression in optimizing combination regimens, minimizing rejection, and toxicities. Different induction immunosuppressive medications are mentioned, such as IL-2 receptor antagonists and thymoglobulin. The speaker also discusses maintenance immunosuppression, which often includes calcineurin inhibitors, mycophenolate, and prednisone. The management of immunosuppression in the ICU is emphasized, taking into account factors such as patient-specific risks, infection concerns, and absorption issues. The second presentation focuses on critical illness after stem cell transplant, particularly respiratory failure. The speaker mentions complications such as infections, graft-versus-host disease, transplant-associated thrombotic microangiopathy, and non-infectious pulmonary complications. The management of these complications, including the use of antimicrobials, steroids, and targeted therapy, is discussed. Finally, the speaker presents an approach to respiratory failure in stem cell transplant patients, emphasizing the importance of early diagnosis, treating underlying causes, and providing aggressive supportive care.

Asset Subtitle

Transplant, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives Explore the array of immunosuppressive medications and infection prophylactics in transplant patients and management in the setting of critical illness Develop an approach to sepsis in transplant patients, including recognizing atypical sepsis presentations, initiating appropriate diagnostics, and implementing empiric therapies to treat the broader range of infections affecting this population Develop an approach to unique critical illness syndromes in stem cell transplant (SCT) patients, including graft-versus-host disease and SCT-specific syndromes resulting in respiratory failure

So Many Transplant Drugs, So Little Time Alley J. Killian Critical Illness After Stem Cell Transplantation Jennifer A. McArthur

Meta Tag

Content Type Presentation

Knowledge Area Transplant

Knowledge Level Advanced

Membership Level Select

Tag Transplant

Tag Stem Cells

Year 2021

Keywords

transplant patients

immunosuppressive medications

stem cell transplant

critical care

respiratory failure

complications

supportive care

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