SCCM Resource Library-Ceftriaxone to Prevent Early Ventilator-Associated Pneumonia in Brain-Injured Patients: A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Assessor-Masked Superiority Trial (Lancet Respiratory Medicine)

Ceftriaxone to Prevent Early Ventilator-Associated Pneumonia in Brain-Injured Patients: A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Assessor-Masked Superiority Trial (Lancet Respiratory Medicine)

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Video Transcription

Video Summary

The Profi-Viper trial, presented in this video, explored the effectiveness of a single dose of ceftriaxone in preventing ventilator-associated pneumonia (VAP) in comatose brain-injured ICU patients. Conducted over a decade, the randomized controlled trial included brain injury patients who needed prolonged mechanical ventilation. Results showed ceftriaxone significantly reduced early and overall VAP incidence compared to the placebo, improved antibiotic and ventilator-free days, and enhanced mortality and prognosis at 28 days. Safety assessments found minimal differences in negative outcomes. This trial supports ceftriaxone use in reducing VAP without increasing antibiotic resistance.

Asset Caption

Thought Leader | Thought Leader: Late-Breaking Studies That Will Change Your Practice

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

Profi-Viper trial

ceftriaxone

ventilator-associated pneumonia

brain injury patients

ICU

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