SCCM Resource Library-Chasing the Dream of Equipoise: Design and Execution Challenges of Multicenter Trial Design in Pediatric ECMO

Chasing the Dream of Equipoise: Design and Execution Challenges of Multicenter Trial Design in Pediatric ECMO

Video Transcription

Video Summary

Lynn, the research director at Boston Children's Hospital, discusses the challenges in achieving equipoise in pediatric ECMO trials, using the TITRE trial as a primary example. The 20-center North American randomized trial aims to determine if restricting blood transfusion improves organ function and long-term outcomes for children on ECMO. Lynn highlights the complexities of site selection, stakeholder engagement, and protocol compliance, emphasizing the need for balance between trial feasibility and scientific rigor. The trial involves modifying protocols for inclusivity, ensuring participation while maintaining rigorous research standards. The team currently works with 20 sites and has randomized 52 of 228 target patients.

Asset Caption

One-Hour Concurrent Session | Can We Improve Outcomes in Pediatric ECMO With Clinical Research?

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

pediatric ECMO trials

TITRE trial

blood transfusion

protocol compliance

stakeholder engagement

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.