SCCM Resource Library-Chloride

Video Transcription

Video Summary

Over the past five to ten years, there has been a growing interest in chloride and its importance in the body. Chloride plays a role in various systems and functions, including electrolyte balance, fluid secretion, blood pressure regulation, and neuromuscular function. One of the most significant examples of chloride's essential nature is cystic fibrosis, a mutation in a chloride channel that can have catastrophic effects. Chloride homeostasis primarily occurs in the gastrointestinal tract and kidneys. In the kidneys, chloride is reabsorbed along with sodium in the proximal tubule, loop of Henle, and distal nephron. In the gastrointestinal tract, chloride is secreted in association with fluid movement. Abnormal chloride levels can have adverse effects on health. Both hypochloremia (low chloride) and hyperchloremia (high chloride) have been associated with increased mortality rates. Though the exact mechanisms are not fully understood, studies suggest that hyperchloremia may lead to acute kidney injury and altered renal blood flow. Further research is needed to fully understand chloride's role and its potential therapeutic implications.

Asset Subtitle

Professional Development and Education, Pharmacology, 2020

Asset Caption

This is a presentation from the 2020 Critical Care Congress precourse, Cardiopulmonary Resuscitation, Electrolyte, and Acid-Base Disorders for the Veterinary Emergency and Critical Care Specialist. Chloride was presented by Katrina Hopper, DVM, BVSc.

The course covered topics including updates from research, electrolyte disorders commonly and less commonly seen in the critical care setting, importance of chloride and its role in resuscitation management and the kidney, and acid-base disorders, including physiology, blood gas interpretation, and treatment.

Meta Tag

Content Type Presentation

Knowledge Area Professional Development and Education

Knowledge Area Pharmacology

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Veterinary Medicine

Tag Electrolytes

Year 2020

Keywords

chloride

body

electrolyte balance

fluid secretion

blood pressure regulation

neuromuscular function

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