SCCM Resource Library-Coagulation in Acute Liver Failure: Bleeding Versus Prothrombotic State

Coagulation in Acute Liver Failure: Bleeding Versus Prothrombotic State

Video Transcription

Video Summary

Dr. Yonca Bulut, a Professor of Pediatric Critical Care at UCLA Mattel Children's Hospital, discusses the management of Pediatric Acute Liver Failure in the Pediatric ICU. The definition of pediatric acute liver failure includes coagulopathy that is not corrected by vitamin K. The etiology of liver failure can determine the outcome and likelihood of recovery. Coagulopathy in acute liver failure affects all three arms of hemostasis. Platelet numbers and function, as well as production of procoagulant and anticoagulant factors, are reduced. Spontaneous bleeding is rare, but there is an increased risk of thrombosis. Standard hemostasis tests have limitations, while viscoelastic assays offer better evaluation of coagulability. Current guidelines for correcting coagulopathy in acute liver failure are limited, with a focus on treating bleeding or using specific cutoff values for procedures.

Asset Subtitle

GI and Nutrition, Hematology, 2023

Asset Caption

Type: two-hour concurrent | Liver Failure in the Pediatric ICU: Current Controversies (Pediatrics) (SessionID 1191837)

Meta Tag

Content Type Presentation

Knowledge Area GI and Nutrition

Knowledge Area Hematology

Membership Level Professional

Membership Level Select

Tag Liver

Tag Coagulation

Year 2023

Keywords

Pediatric Acute Liver Failure

Management

Pediatric ICU

Coagulopathy

Viscoelastic assays

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