SCCM Resource Library-Conducting Post Hoc Analyses Using Clinical Trial Data

Video Transcription

Video Summary

In this webcast, Dr. Bram Rochberg discusses the benefits and restrictions of conducting post-hoc analyses using clinical trial data. He introduces the Iceman tool, which is used to assess the credibility of subgroup effects, and highlights the importance of pre-specification and prior evidence in subgroup analyses. Dr. Rochberg also discusses the potential risks and limitations of post-hoc analyses, such as confounding and multiple testing. He emphasizes the need for caution in interpreting and applying subgroup findings, especially in post-hoc analyses, and recommends considering the credibility of the findings based on the Iceman tool. Dr. Rochberg mentions the increasing popularity of post-hoc analyses, including re-analyses and meta-analyses, and suggests involving knowledgeable collaborators and biostatisticians early on when designing new trials. He concludes by highlighting the complexity and variability of post-hoc analyses and the need for careful interpretation and application of the findings.

Asset Subtitle

Professional Development and Education, Research, 2022

Asset Caption

Clinical trials are resource-intensive exercises that provide valuable information to guide the approach to clinical care. Although uncommon in critical care, the amount of data and knowledge generated from clinical trials may extend far beyond the initial aims. This webcast provides an overview of post hoc analyses using clinical trial data. Topics include:

Prespecified versus newly generated analyses
Using stored specimens for additional testing
Limitations of using clinical trial data in the post hoc setting

Meta Tag

Content Type Webcast

Knowledge Area Professional Development and Education

Knowledge Area Research

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Professional

Membership Level Select

Tag Professional Development

Tag Clinical Research Design

Year 2022

Keywords

post-hoc analyses

clinical trial data

Iceman tool

subgroup effects

pre-specification

confounding

multiple testing

interpretation

application

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.